DNA methylation is an important epigenetic modification that influences diverse biological processes and is highly relevant to development and response to stress. The developed single molecule real-time (SMRT) sequencing provides an efficient solution to detect N6-methyladenine (6mA) and N4-methylcytosine (4mC) modification at single-nucleotide resolution. Recently, Fragaria vesca and Rosa chinensis of Rosaceae family were sequenced by SMRT. The published datasets were collected and used for further 6mA and 4mC modification detection.
MDR (Methylation Database for Rosaceae) is an integrative database for storing, analyzing and visualizing of DNA m6A and m4C methylation in Rosaceae. It provides a user-friendly interface to host, browse, search and download m6A and m4C profiles and also offers a genome browse to visualize DNA methylation sites and related coverage and gene annotation. The MDR will become a powerful tool to provide a genome-wide view of DNA 6mA and 4mC methylation in Rosaceae.
The MDR database is released
Related documents were integrated to facilitate usability of MDR
All collected datasets analysis completed and updated
Publication resources were collected